The Worldwide Registry on the Management of Helicobacter Pylori Infection (WorldHpReg) is the union of multiple international prospective multicentre registries on managing Helicobacter pylori infection and its treatment in gastroenterologists' clinical practice.

WorldHpReg was launched in 2021 under the impulse of the European Registry on Helicobacter pylori Management (Hp-EuReg) and currently involves the regions of Latin America, Africa, Australia, Canada, the Association of Southeast Asian Nations, the United States, Pakistan, Saudi Arabia, India, Jordan and New Zealand.

What is the aim?

The great diversity of regimens and treatment lines for Helicobacter pylori eradication and their varying efficacy, mainly due to increasing bacterial antibiotic resistance and regional differences, require continuous critical analysis of clinical practice. This requires systematically assessing the efficacy and safety of various regimens and the cost-effectiveness of different diagnostic-therapeutic strategies.

A global registry on managing H. pylori can help design effective and optimised treatments that reduce the number of retreatments, diagnostic tests and the occurrence of associated pathologies such as peptic ulcers and gastric cancers. Therefore, evaluating actual clinical practice through non-interventional registries can help improve the design and organisation of a Consensus on managing H. pylori infection in each territory. According to the available evidence, this is the best way to innovate new therapies efficiently.

Finally, there is generally a delay from the publication of recommendations to their implementation in routine clinical practice, sometimes reaching full penetration after they have become obsolete. Long-term studies assessing practice and outcome trends and tools capable of providing real-time data from actual clinical practice (local, regional and global) are essential. Therefore, the main objective of WorldHpReg is to obtain a database that systematically records a large and representative sample of the routine clinical practice of gastroenterologists in each territory to produce descriptive studies of the management of H. pylori infection. This will allow the design of innovative therapeutic strategies according to the evidence, available drugs and accessibility to health technologies.

Hp-AfricaReg

This prospective multicenter registry of the clinical practice of African gastroenterologists on the management of Helicobacter pylori infection and its treatment is supported by African Helicobacter and Microbiota Study Group (AHMSG). Join the project at https://redcap.link/hpafricareg.